Peganum Harmala

Peganum harmala · Syrian rue · esfand

Syrian rue seeds, from esfand smoke to MAOI risks

Syrian rue (Peganum harmala) is a desert perennial whose small brown seeds have been burned as incense for at least 2,700 years and used to dye wool. The same seeds hold about 4 percent harmine and 5 percent harmaline, alkaloids that block the enzyme MAO-A. That makes them a serious interaction risk with many medicines, drugs and some foods, and toxic when swallowed.

about 500
seeds in a gram
2,700 years
of harmal smoke, dated at Qurayyah
MAO-A
blocked by harmine and harmaline

Choose a bag at Avalon Magic Plants From €6.95 · 25 to 1000 g · adults only

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The seed

A gram holds roughly 500 seeds: dark brown, angular and about 1.8 mm long (Li et al., 2023). They ripen in leathery capsules, 45 to 60 to a capsule. Sown on the surface in warmth they germinate within two weeks, and they are also the most toxic part of the plant. Read the growing guide.

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The plant

A bushy perennial of 30 to 70 cm with fleshy, finely divided leaves and white five-petalled flowers from spring into early autumn. It grows wild from Morocco and Spain to Central Asia and northern China. In the American West, where it was first recorded in 1920, it is a listed noxious weed. More on the plant and where it grows.

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Smoke and dye

Iron Age censers from Qurayyah in northwest Arabia carry harmal residue dated to about 2,700 years ago. In Iran and its neighbours the seeds are still dropped on glowing charcoal as esfand, against the evil eye. Elsewhere they coloured wool; the famous Turkey red came from madder root instead. Read the history of esfand smoke and harmal dye.

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Caution

Harmine and harmaline block MAO-A strongly: in one laboratory study, seed extract halved the enzyme's activity at 27 micrograms per litre. Together with antidepressants, several other medicines, stimulants or food rich in tyramine, that can cause serotonin syndrome or a dangerous rise in blood pressure. Poison centres have recorded deaths after people swallowed the seeds. Keep them away from children, pets and anyone on serotonergic medicine, and read risks and documented poisonings.

The product

Seed specification

PropertyValue
Botanical namePeganum harmala L. (Nitrariaceae)
Other namesSyrian rue, wild rue, African rue, harmal, esfand
Seed sizeabout 1.8 mm, three-sided
Seeds per gramabout 500
Germination in the lab94 % at 25/10 °C and 30/15 °C, with light
Main alkaloidsharmaline 5.6 %, harmine 4.3 % (one study)
Offered forgrowing and collecting, not for consumption
Legal to buyNetherlands, UK, Germany; not in France or Oregon

Small to large

Choose your bag

Avalon Magic Plants sells the seeds in five sizes. Every bag holds the same seed; the size only decides how far it goes. Seed counts below are estimates from the published seed weight.

BagRoughlySuits
25 g12,500 seedsa few garden plants and a first pinch of esfand
100 g50,000 seedsesfand through the year
250 g125,000 seedsfirst dye tests on small skeins of wool
500 g250,000 seedsdyeing larger amounts of wool
1000 g500,000 seedsworkshop dye projects

The shop sells to adults only and offers the seeds strictly for horticultural use. Order only where they are legal: the law page covers the Netherlands, the UK, Germany, the United States and France.

Choose your bag at Avalon Magic Plants